Roll the chilled mac and cheese into bite-sized balls (about 1-2 tablespoons each).
In a small bowl, whisk together eggs and milk.
In another bowl, mix Panko, Parmesan, salt, pepper, garlic powder, and onion powder.
Dip each mac and cheese ball into the egg mixture, then coat thoroughly with the breadcrumb mixture.
Preheat air fryer to 375°F (190°C). Lightly spray the basket with oil.
Place coated bites in the air fryer basket in a single layer, without overcrowding.
Air fry for 8-12 minutes, until golden brown and crispy.
Serve immediately with your favorite dipping sauces.